Scientific Resources
MAVDA members now have access to CDD Vault!
The Collaborative Drug Discovery (CDD) Vault is a complete informatics platform hosted through an intuitive interface. It helps project teams manage, analyze, and present data.
Publications
Identifying Structural Features of Nucleotide Analogues to Overcome SARS-CoV-2 Exonuclease Activity
Xuanting Wang, Chuanjuan Tao, Irina Morozova, Sergey Kalachikov, Xiaoxu Li, Shiv Kumar, James J Russo, Jingyue Ju
Viruses, 2022
PMCID: PMC9324094
PMID: 35891393
DOI: 10.3390/v14071413
Commercially Available Flavonols Are Better SARS-CoV-2 Inhibitors than Isoflavone and Flavones
Otávio Augusto Chaves, Natalia Fintelman-Rodrigues, Xuanting Wang 3 4, Carolina Q Sacramento, Jairo R Temerozo, André C Ferreira, Mayara Mattos, Filipe Pereira-Dutra, Patrícia T Bozza, Hugo Caire Castro-Faria-Neto, James J Russo,
Jingyue Ju, Thiago Moreno L Souza
Viruses, 2022
PMID: 35891437
PMCID: PMC9324382
DOI: 10.3390/v14071458
Selected MAVDA-related publications from MAVDA consortium members
2023
The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor In Vitro and Confer Resistance To Nirmatrelvir
Dirk Jochmans, Cheng Liu, Kim Donckers, Antitsa Stoycheva, Sandro Boland, Sarah K Stevens, Chloe De Vita, Bert Vanmechelen, Piet Maes, Bettina Trüeb, Nadine Ebert, Volker Thiel, Steven De Jonghe, Laura Vangeel, Dorothée Bardiot, Andreas
Jekle, Lawrence M Blatt, Leonid Beigelman, Julian A Symons, Pierre Raboisson, Patrick Chaltin, Arnaud Marchand, Johan Neyts, Jerome Deval, Koen Vandyck
mBio, 2023
PMID: 36625640
DOI: 10.1128/mbio.02815-22
2022
Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants
Qian Wang, Sho Iketai, Zhiteng Li , Liyuan Liu, Yicheng Guo, Yiming Huang, Anthony D Bowen, Michael Liu, Maple Wang, Jian Yu, Riccardo Valdez, Adam S Lauring, Zizhang Sheng, Harris H Wang, Aubree Gordon, Lihong Liu,
David D Ho
Cell, 2022
PMID: 36580913
PMCID: PMC9747694
DOI: 10.1016/j.cell.2022.12.018
Multiple pathways for SARS-CoV-2 resistance to nirmatrelvir
Sho Iketani #, Hiroshi Mohri #, Bruce Culbertson #, Seo Jung Hong #, Yinkai Duan, Maria I Luck, Medini K Annavajhala, Yicheng Guo, Zizhang Sheng, Anne-Catrin Uhlemann, Stephen P Goff,
Yosef Sabo, Haitao Yang, Alejandro Chavez, David D Ho
Nature, 2022
PMID: 36351451
DOI: 10.1038/s41586-022-05514-2
Discovery of SARS-CoV-2 antiviral synergy between remdesivir and approved drugs in human lung cells
Xammy Nguyenla, Eddie Wehri, Erik Van Dis, Scott B Biering, Livia H Yamashiro, Chi Zhu, Julien Stroumza, Claire Dugast-Darzacq, Thomas G W Graham, Xuanting Wang, Steffen Jockusch, Chuanjuan Tao, Minchen Chien, Wei Xie,
Dinshaw J Patel, Cindy Meyer, Aitor Garzia, Thomas Tuschl, James J Russo, Jingyue Ju, Anders M Näär, Sarah Stanley, Julia Schaletzky
Sci Rep, 2022
PMID: 36323770
PMCID: PMC9628577
DOI: 10.1038/s41598-022-21034-5
Combination of antiviral drugs inhibits SARS-CoV-2 polymerase and exonuclease and demonstrates COVID-19 therapeutic potential in viral cell culture
Xuanting Wang, Carolina Q Sacramento, Steffen Jockusch, Otávio Augusto Chaves, Chuanjuan Tao, Natalia Fintelman-Rodrigues, Minchen Chien, Jairo R Temerozo, Xiaoxu Li, Shiv Kumar, Wei Xie, Dinshaw J Patel, Cindy Meyer,
Aitor Garzia, Thomas Tuschl, Patrícia T Bozza, James J Russo, Thiago Moreno L Souza, Jingyue Ju
Commun Biol, 2022
PMID: 35194144
PMCID: PMC8863796
DOI: 10.1038/s42003-022-03101-9
Randomized, double-blind, controlled trial of human anti-LIGHT monoclonal antibody in COVID-19 acute respiratory distress syndrome
David S Perlin, Garry A Neil, Colleen Anderson, Inbal Zafir-Lavie, Shane Raines, Carl F Ware, H Jeffrey Wilkins
J Clin Invest, 2022
PMID: 34871182
PMCID: PMC8803341
DOI: 10.1172/JCI153173
A potent and broad neutralization of SARS-CoV-2 variants of concern by DARPins
Vikas Chonira, Young D Kwon, Jason Gorman, James Brett Case, Zhiqiang Ku, Rudo Simeon, Ryan G Casner, Darcy R Harris, Adam S Olia, Tyler Stephens, Lawrence Shapiro, Michael F Bender, Hannah Boyd, I-Ting Teng, Yaroslav
Tsybovsky, Florian Krammer, Ningyan Zhang, Michael S Diamond, Peter D Kwong, Zhiqiang An, Zhilei Chen
Nat Chem Biol, 2022
PMID: 36411391
DOI: 10.1038/s41589-022-01193-2
Functional map of SARS-CoV-2 3CL protease reveals tolerant and immutable sites
Sho Iketani, Seo Jung Hong, Jenny Sheng, Farideh Bahari, Bruce Culbertson, Fereshteh Fallah Atanaki, Arjun K Aditham, Alexander F Kratz, Maria I Luck, Ruxiao Tian, Stephen P Goff, Hesam Montazeri,
Yosef Sabo, David D Ho, Alejandro Chavez
Cell Host Microbe, 2022
PMID: 36029764
PMCID: PMC9365866
DOI: 10.1016/j.chom.2022.08.003
Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2
Lihong Liu # 1, Sho Iketani #, Yicheng Guo #, Jasper F-W Chan #, Maple Wang #, Liyuan Liu #, Yang Luo, Hin Chu, Yiming Huang, Manoj S Nair, Jian Yu, Kenn K-H Chik, Terrence T-T Yuen, Chaemin Yoon, Kelvin K-W To, Honglin Chen, Michael T
Yin, Magdalena E Sobieszczyk, Yaoxing Huang, Harris H Wang, Zizhang Sheng, Kwok-Yung Yuen, David D Ho
Nature, 2022
PMID: 35016198
DOI: 10.1038/s41586-021-04388-0
2021
Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks
William M Schneider, Joseph M Luna, H-Heinrich Hoffmann, Francisco J Sánchez-Rivera, Andrew A Leal, Alison W Ashbrook, Jérémie Le Pen, Inna Ricardo-Lax, Eleftherios Michailidis, Avery Peace, Ansgar F Stenzel, Scott W Lowe, Margaret R
MacDonald, Charles M Rice, John T Poirier
Cell, 2021
PMID: 33382968
PMCID: PMC7796900
DOI: 10.1016/j.cell.2020.12.006
Replication and single-cycle delivery of SARS-CoV-2 replicons
Inna Ricardo-Lax, Joseph M Luna, Tran Thi Nhu Thao,… Margaret R MacDonald, Volker Thiel, Charles M Rice
Science, 2021
PMID: 34648371
PMCID: PMC9007107
DOI: 10.1126/science.abj8430
Diagnosis, clinical characteristics, and outcomes of COVID-19 patients from a large healthcare system in northern New Jersey
Yanan Zhao, Marcus H Cunningham, Jose R Mediavilla, Steven Park, Sean Fitzgerald, Hee Sang Ahn, Xiangyang Li, Caixin Zhan, Tao Hong, Gary Munk, Kar Fai Chow, David S Perlin
Sci Rep, 2021
PMID: 33623090
PMCID: PMC7902820
DOI: 10.1038/s41598-021-83959-7
A novel diagnostic test to screen SARS-CoV-2 variants containing E484K and N501Y mutations
Yanan Zhao, Annie Lee, Kaelea Composto, Marcus H Cunningham, Jose R Mediavilla, Samantha Fennessey, André Corvelo, Kar Fai Chow, Michael Zody, Liang Chen, Barry N Kreiswirth, David S Perlin
Emerg Microbes Infect, 2021
PMID: 33977858
PMCID: PMC8168736
DOI: 10.1080/22221751.2021.1929504
ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model
Koen Vandyck, Rana Abdelnabi, Kusum Gupta, Dirk Jochmans, Andreas Jekle, Jerome Deval, Dinah Misner, Dorothée Bardiot, Caroline S Foo, Cheng Liu, Suping Ren, Leonid Beigelman, Lawrence M Blatt, Sandro Boland, Laura Vangeel, Steven
Dejonghe, Patrick Chaltin, Arnaud Marchand, Vladimir Serebryany, Antitsa Stoycheva, Sushmita Chanda, Julian A Symons, Pierre Raboisson, Johan Neyts
Biochem Biophys Res Commun, 2021
PMID: 33813272
PMCID: PMC7997389
DOI: 10.1016/j.bbrc.2021.03.096